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This year marked the first time the Academy Awards was hosted by two people.
Actors and comedians Alec Baldwin and Steve Martin hosted the 82nd annual award show.
2009 Best Supporting Actress Oscar winner Penelope Cruz presented the first award of the night for Best Supporting Actor.
The nominees included Matt Damon, Woody Harrelson, Christopher Plummet, Stanley Tucci and Christoph Waltz.
Waltz won the award for his role as an aggressive "Jew hunter" in "Inglourious Basterds."
Considering that last year's Academy Award winner for Best Supporting Actor went to the late Heath Ledger for "The Dark Knight," actor and stand-up comedian Robin Williams, in Ledger's place, presented the trophy for 2010's Best Supporting Actress.
Much like Waltz's expected win, late night TV host/comedian/actress Mo'Nique picked up the Academy Award for her role as a monster of a mother in "Precious."
Favorite "The Hurt Locker," picked up three awards by mid-evening for Sound Editing, Sound Mixing, and Original Screenplay.
Blockbuster "Avatar," which like "The Hurt Locker" was also up for nine Oscars, picked up three awards for Art Direction, Best Cinematography and Best Visual Effects.
Though the award for Best Adapted Screenplay was assumed to go to Jason Reitman for "Up in the Air," the Oscar instead went to Geoffrey Fletcher for "Precious."
Kate Winslet announced Jeff Bridges as Best Actor in a Leading Role for his performance in "Crazy Heart."
Sean Penn announced Sandra Bullock for Best Actress in a Leading Role for "The Blind Side."
Bullock delivered the night's most humorous, heartfelt speech of the evening and accepted the Oscar with grace.
"We are all deserving of love," she said and jokingly thanked the 16-time nominee Meryl Streep for being her "lover."
Singing superstar Barbra Streisand appeared on the Oscar stage for the coveted Best Director.
Kathryn Bigelow, the only woman in the director category, made Oscar history by becoming the first female to receive the Academy Award in the Best Director category for "The Hurt Locker."
The night's biggest award, Best Picture, was the last category to be announced for the evening.
Actor Tom Hanks approached the stage to announce the winner to be "The Hurt Locker."
The night's biggest award winner was "The Hurt Locker," which picked up six Academy Awards Sunday evening. Close followers included three wins for "Avatar" and two for the animated "Up" and Tyler Perry and Oprah's "Precious."